Other interactions include [BNF 76, 2018]: Simvastatin is contraindicated in patients with active hepatic disease including cholestasis, hepatic encephalopathy, hepatitis, jaundice or unexplained persistent elevations … Also patients who have a liver disease should not take Simvastatin. In patients taking simvastatin 80 mg for whom an interacting agent is needed, a lower dose of simvastatin or an alternative statin-based regimen with less potential for drug-drug interactions should be used (see below Measures to reduce the risk of myopathy caused by medicinal product interactions and sections 4.2, 4.3, and 4.5). updated advice on simvastatin interactions. Drug interactions are reported among people who take Losartan and Simvastatin. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Simvastatin Mylan tablets may be taken with or without food. Common interactions include diarrhoea among females and dyspnoea among males. Nursing considerations Assessment. Simvastatin is used to reduce the level of bad cholesterol in the body. A full list of contraindications can be found in the leaflet. • Pregnancy and breast-feeding (see also section 4.6). Patients currently tolerating the fixed-combination preparation containing 10 mg of ezetimibe and 80 mg of simvastatin who require therapy with an interacting drug (i.e., a drug with which concomitant use is contraindicated or is associated with a dose limit for simvastatin) should be switched to an alternative statin or statin-based regimen with less drug interaction potential. Dosing : <10 years: Safety and efficacy not established. [See Contraindications (4) and Drug Interactions (7.1).] memory loss. Temporary suspension of simvastatin treatment may be considered. simvastatin oral and warfarin oral simvastatin oral, warfarin oral. No drug interaction studies were conducted with SIMCOR. (5.1) • Liver enzyme abnormalities and monitoring: Persistent elevations in hepatic transaminase can occur. Liver function tests should be carried out. In general, the potential for inhibition of statin metabolism is as follows: simvastatin and lovastatin > atorvastatin and rosuvastatin >> pravastatin. © 2005 - 2019 WebMD LLC. Drug Name Generic Name : simvastatin Brand Name: Apo-Simvastatin (CAN), Gen-Simvastatin (CAN), CO Simvastatin (CAN), Novo-Simvastatin (CAN), ratio-Simvastatin (CAN), Zocor Classification: Antihyperlipidemic, HMG-CoA reductase inhibitor Pregnancy Category X Dosage & Route Available forms : Tablets—5, 10, 20, 40, 80 mg ADULTS Initially, 20 mg PO; up to 80 mg PO daily in the evening. You can change your cookie settings at any time. Simvastatin drug interactions. 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